Building Biomolecules for Therapeutics and Diagnostics: Enhancing ADCs, Replacing ELISA

Antibodies are important biological scaffolds used in biotherapeutics and diagnostics. The utility of antibodies can be expanded by coupling them with small-molecule drugs or proteins. Using both protein engineering and bioconjugation chemistry, we created a series of highly-characterized antibody-conjugates that simultaneously deliver multiple drugs to induce new forms of synthetic lethality. We are able to demonstrate the applicability against HER2 positive cancers, and drug-resistant bacteria