Biochemistry Colloquium: Mark Denison

Mark Denison is a Professor of Pediatrics as well as Pathology, Microbiology and Immunology at VUMC. He studies coronaviruses using molecular genetics. His work has shown that a viral exonuclease has a chief role in proofreading nucleotide mismatches that occur during viral RNA replication and that this proofreading provides coronaviruses with natural resistance to many nucleoside analogue drugs. Importantly, Dr. Denison's work has directly contributed to the development of remdesivir and molnup