Statistics Seminar

Abstract: We investigate the robustness of the model-X knockoffs framework with respect to the misspecified or estimated feature distribution. We achieve such a goal by theoretically studying the feature selection performance of a practically implemented knockoffs algorithm, which we name as the approximate knockoffs (ARK) procedure, under the measures of the false discovery rate (FDR) and $k$-familywise error rate ($k$-FWER). The approximate knockoffs procedure differs from the model-X knockoffs procedure only in that the former uses the misspecified or estimated feature distribution. A key technique in our theoretical analyses is to couple the approximate knockoffs procedure with the model-X knockoffs procedure so that random variables in these two procedures can be close in realizations. We prove that if such coupled model-X knockoffs procedure exists, the approximate knockoffs procedure can achieve the asymptotic FDR or $k$-FWER control at the target level. We showcase three specific constructions of such coupled model-X knockoff variables, verifying their existence and justifying the robustness of the model-X knockoffs framework. Additionally, we formally connect our concept of knockoff variable coupling to a type of Wasserstein distance.